ginsenoside-rc from panax quinquefolium (american ginseng)root
ginsenoside rc
CAS: 11021-14-0
Molecular Formula: C53H90O22
ginsenoside-rc from panax quinquefolium (american ginseng)root - Names and Identifiers
ginsenoside-rc from panax quinquefolium (american ginseng)root - Physico-chemical Properties
| Molecular Formula | C53H90O22 |
| Molar Mass | 1079.27 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Melting Point | 199～201℃ |
| Boling Point | 1128.3±65.0 °C(Predicted) |
| Specific Rotation(α) | (c, 1 in MeOH)+1.9 |
| Flash Point | 636.2°C |
| Solubility | H2O : 50 mg/mL (46.33 mM; Need ultrasonic) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White powder (ethanol-n-butanol 1:5) |
| Color | White to Pale Yellow |
| pKa | 12.85±0.70(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Stability | Hygroscopic |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.621 |
| MDL | MFCD00133368 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from ginseng rhizome. |
| In vitro study | Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances γ-aminobutyric acid (GABA) receptor A (GABA A )-mediated ion channel currents. Ginsenoside Rc enhances GABA-mediated ion currents in oocytes expressing the GABA A receptor. Ginsenoside Rc significantly inhibits the expression of macrophage-derived cytokines, such as TNF-α and IL-1β. Ginsenoside Rc also markedly suppresses the activation of TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Ginsenoside Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling. Ginsenoside Rc suppresses the nuclear translocation of phospho-ATF-2 and phospho-FRA-1, whereas the translocation of p65 at its peak time points (30 and 60 min) is not decreased by Ginsenoside Rc treatment. Ginsenoside Rc regulates the expression of the proinflammatory cytokine TNF-α, which is produced by macrophages, by suppressing AP-1 activation. |
ginsenoside-rc from panax quinquefolium (american ginseng)root - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | LY9536300 |
| HS Code | 29389090 |
ginsenoside-rc from panax quinquefolium (american ginseng)root - Reference
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[IF=4.142] Wang Chenxi et al."Rapid discovery of potential ADR compounds from injection of total saponins from Panax notoginseng using data-independent acquisition untargeted metabolomics."Analytical And Bioanalytical Chemistry. 2021 Oct 26 58. [IF=3.935] Ruimei Lin et al."Global identification and determination of the major constituents in Kai-Xin-San by ultra-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry and gas chromatography-mass spectrometry."J Pharmaceut Biomed. 2021 Nov;206 59. [IF=3.845] Zhang Yu et al."Integrating Pharmacokinetics Study, Network Analysis, and Experimental Validation to Uncover the Mechanism of Qiliqiangxin Capsule Against Chronic Heart Failure."Front Pharmacol. 2019 Sep;0:1046 60. [IF=3.69] Xiaoping Wang et al."Baoyuan decoction ameliorates apoptosis via AT1-CARP signaling pathway in H9C2 cells and heart failure post-acute myocardial infarction rats."J Ethnopharmacol. 2020 Apr;252:112536 61. [IF=3.659] Zhang Sheng et al."Protective effect of Shenmai injection on doxorubicin-induced cardiotoxicity via regulation of inflammatory mediators."Bmc Complem Altern M. 2019 Dec;19(1):1-10 62. [IF=3.647] Wenqi Jin et al."Ginsenoside Rd attenuates ACTH-induced corticosterone secretion by blocking the MC2R-cAMP/PKA/CREB pathway in Y1 mouse adrenocortical cells."Life Sci. 2020 Mar;245:117337 63. [IF=3.645] Mengmeng Jia et al."UHPLC coupled with mass spectrometry and chemometric analysis of Kang-Ai injection based on the chemical characterization, simultaneous quantification, and relative quantification of 47 herbal alkaloids and saponins."J Sep Sci. 2020 Ju 64. [IF=3.361] Yuhao Zhang et al."An integrated approach for structural characterization of Gui Ling Ji by traveling wave ion mobility mass spectrometry and molecular network."Rsc Adv. 2021 Apr;11(26):15546-15556 65. 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ginsenoside-rc from panax quinquefolium (american ginseng)root - Reference Information
| biological activity | Ginsenoside Rc is one of the main ginsenosides, Ginsenoside Rc enhances GABA receptor A (GABAA)-mediated ion channels (IGABA). Ginsenoside Rc also inhibited TNF-α and IL-1β expression. |
| Target | TNF-α IL-1β |
| in vitro study | Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances γ-aminobutyric acid (GABA) receptor A (GABA A )-mediated ion channel currents. Ginsenoside Rc enhances GABA-mediated ion currents in oocytes expressing the GABA A receptor. Ginsenoside Rc significantly inhibits the expression of macrophage-derived cytokines, such as TNF-α and IL-1β. Ginsenoside Rc also markedly suppresses the activation of TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Ginsenoside Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling. Ginsenoside Rc suppresses the nuclear translocation of phospho-ATF-2 and phospho-FRA-1, whereas the translocation of p65 at its peak time points (30 and 60 min) is not decreased by Ginsenoside Rc treatment. Ginsenoside Rc regulates the expression of the proinflammatory cytokine TNF-α, which is produced by macrophages, by suppressing AP-1 activation. |
| chemical properties | white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from ginseng rhizome. |
| use | applied to the medical and health care industry, it can be formulated into anti-fatigue, anti-aging and brain-strengthening health food; ginsenoside Rc belongs to steroid and triterpene saponins, which are unique in ginseng plants and have the growth characteristics of inhibiting or preventing tumors. |
Last Update：2024-04-09 20:52:54
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Product Name: Ginsenoside Rc Visit Supplier Webpage Request for quotationCAS: 11021-14-0
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